The conformations are distinctively different for the two independent molecules of the free base, the two independent molecules of the hydrofumarate salt, and the one unique cation of the benzoate salt. The flexible backbone of the bedaquiline structure leads to a landscape of conformations with little commonalities between the bedaquiline entities in the various structures. The conformations of the cations are compared to that of free base bedaquiline and with each other.

Both salts feature a 1:1 cation-to-anion ratio, with the fumarate being present as monoanionic hydrofumarate. The much less basic quinoline N atom remains unprotonated. The fumarate and benzoate salts both feature cations monoprotonated at the dimethylamino group. In a first communication, we present the crystal structure of bedaquilinium fumarate and of two new benzoate salts, as well as that of a degradation product of the reaction of bedaquilinium fumarate with sodium ethoxide, 3-benzyl-6-bromo-2-methoxyquinoline, C 17H 14BrNO.

It is marketed in the US as its fumarate salt, and about a dozen other salts of bedaquiline have been described in patent literature, but none have so far been structurally described. On Twitter, Facebook, Google News, and Instagram.Bedaquiline is one of two important new drugs for the treatment of drug-resistant tuberculosis (TB). You can continue using the current service and you will have access to 1TB of storage to store files, documents, and other stuff without any extra charges.įollow HT Tech for the latest tech news and reviews, also keep up with us The storage expansion update will be done automatically without you having to lift a finger! Google will automatically upgrade the storage cloud data limit on every Google Workspace account from 15GB to 1TB. Therefore, if you have a Google Workspace account, you could soon take advantage of the hefty 1TB storage space! How to upgrade storage to 1TB storage on Google? However, it only applies to Google Workspace users and not free users. 210 per month for 200GB storage and Rs.650 per month for a hefty 2TB storage. At present, you can expand the 15GB free storage space by paying to upgrade.

Free Google Drive 76.0.3